Torunn Fiskerstrand.

Knappskog, Ph.D.: Familial Diarrhea Syndrome Caused by an Activating GUCY2C Mutation Chronic diarrhea is usually a ongoing health problem that poses challenges with respect to both diagnosis and treatment. The irritable bowel syndrome impacts 15 to 20 percent of adults and can be a common cause of diarrhea.1 Other notable causes consist of inflammatory bowel disease, attacks, paraneoplastic hormones, celiac disease, malabsorption syndromes, and bacterial overgrowth in the small intestine.2 In addition to organic causes, psychological elements have an important influence on bowel function.1 Recent studies have focused on the need for genetic factors in the development of chronic diarrhea3-5 because genetic factors can offer insight into the pathophysiology of intestinal diseases and indicate new treatments.In a previous study assessing the relationship between early and childhood neurologic assessments later, the sensitivity of the 1-year evaluation in predicting the 5-year neurologic outcome was 96 percent, and the sensitivity of the Mental Developmental Index of the Bayley Scales of Infant Development to predict the IQ score was 87 percent.5 We likewise found a high concordance between assessment of moderate-to-severe disability at 18 to 22 months of age and similar assessment at 6 to 7 years of age.