Dialogue The efficacy was studied by us and cardiovascular basic safety of peginesatide in comparison with other ESAs, using the mark hemoglobin level that was the typical when the trials were conducted. For the evaluation of cardiovascular safety, composite safety end-point events were adjudicated by an unbiased event-review committee whose associates were unaware of the group assignments and hemoglobin amounts. Among patients undergoing hemodialysis , peginesatide administered monthly was as effectual as epoetin administered one to three times a week in maintaining hemoglobin levels. Rates of confirmed hemoglobin excursions and transfusions were similar in both groups. Adverse events in the EMERALD research were comparable in the peginesatide and epoetin organizations and were in keeping with expected adverse events in patients undergoing hemodialysis.Zwenneke Flach, M.D., Henk A. Marquering, Ph.D., Marieke E.S. Sprengers, M.D., Ph.D., Sjoerd F.M. Jenniskens, M.D., Ph.D., Ludo F.M. Beenen, M.D.D., Ph.D., Peter J. Koudstaal, M.D., Ph.D., Wim H. Van Zwam, M.D., Ph.D., Yvo B.W.E.M. Roos, M.D., Ph.D., Aad van der Lugt, M.D., Ph.D., Robert J. Van Oostenbrugge, M.D., Ph.D., Charles B.L.M. Majoie, M.D., Ph.D., and Diederik W.J. Dippel, M.D., Ph.D. For the MR CLEAN Investigators: A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke..