Study also indicates that the brains of those predisposed to alcoholism might not create enough dopamine, which has a direct influence over feelings and mood of pleasure. Alcohol increases the degrees of dopamine in the brain, and may stimulate other feel great neurotransmitters such as serotonin. This may hard wire this chemical substance reward system in the mind, building fresh neural pathways that demand alcohol to create these pleasurable emotions. Janice K. Phelps, M.D., believes that an addictive body might be evident in childhood through circumstances such as colic, hyperactivity, loss of rest, irritability, crying, and learning disabilities. She also believes that a long time before a child gets involved in drugs and alcohol, they are generally very addicted to sugar.Many patients had an individual bout of pancreatitis . Some patients had risk factors of prior pancreatitis , alcohol use , or diabetes . None of the episodes of pancreatitis occurred in conjunction with liver-function abnormalities. Most events were self-limited; pancreatitis resolved in a median of 6 days in 13 of 15 events, and 2 events were ongoing during this analysis. Rechallenge was generally successful, although 2 sufferers discontinued ponatinib because of pancreatitis permanently, and 1 patient completely discontinued the drug because of an elevated lipase level.